The study conducted in US on Thursday revealed that low-calorie diet can quickly reverse type 2 diabetes in rats.
It is a potential new drug for treating this common chronic disease. It could help 100 million Americans diagnosed with the disease find some relief.
Type 2 diabetes occurred due to combination of lifestyle and genetic factors. Some of these factors are under personal control, such as diet and obesity.
This is a state of your body either making too much of insulin or not producing any. This is because hormones help glucose to work properly. These insufficient sugars reach cells and stay in blood.
To examine this researchers from Yale gave the animals one-quarter of their typical dietary intake and observed the mechanism of their bodies, especially to insulin resistance and glucose, or sugar, production by the liver, as these two functions can lead to increased blood-sugar levels in diabetics.
The results were positive and demonstrated that the full recovery is also possible not through drugs but through diet. New castle investigation found out this result can be achieved. 11 people with diabetes took part in the study. They cut down their food intake to just 600 calories for 2 months. After 3 months, 7 out of 11 were free from the diabetes.
This low-calorie diet lowered glucose by bringing down the extent of lactate and amino acids in the body which in turn converted into sugar.
Animals on the special diet converted less glycogen in the body to be used as fuel, into glucose. There is also decrease in fat content, which aids the liver reacts to insulin. It took just 3 days to complete this process.
“Using this approach to comprehensively interrogate liver carbohydrate and fat metabolism, we showed that it is a combination of three mechanisms that is responsible for the rapid reversal of hyperglycemia following a very low-calorie diet,” senior author Gerald I. Shulman, M.D., said in a statement. These results, if confirmed in humans, will provide us with novel drug targets to more effectively treat patients with Type 2 diabetes.
In the previous stages the team hopes to see whether this works in humans. Later on a study on patients who have Type 2 diabetes and are undergoing bariatric surgery or are on very low-calorie diets. If the results are altered it can be confirmed that it could lead to new pharma advancements.
“To have people free of diabetes after years with the condition is remarkable – and all because of an eight-week diet,” said Roy Taylor, professor at Newcastle University, who led the study. “This is a radical change in understanding type 2 diabetes. It will change how we can explain it to people newly diagnosed with the condition. While it has long been believed that someone with type 2 diabetes will always have the disease, and that it will steadily get worse, we have shown that we can reverse the condition.”
Losing 5 to 7% of body weight can also help in lowering the risk of diabetes mellitus. Working out for 30 min a day can also help in reducing the risk.